Date Created: June 3, 2022 - 12:38pm
Postdoctoral positions in molecular, cellular and behavioral neuroscience
Job duration: 1 to 5 years
Min Education: Ph.D
Min Experience: 1-2 years
Required travel: None
Location: New York, New York, 10065, United States
Job Description: The Hemmings & Platholi Lab in the Department of Anesthesiology at Weill Cornell Medicine is seeking two accomplished and motivated Postdoctoral Associates to join our neuropharmacology/neuroscience team in investigating the molecular, cellular, and functional mechanisms of anesthetic action.
Project one is to identify the functional consequences of anesthetic effects on synaptic transmission and plasticity. This research will explore transmitter-specific effects of general anesthetics at hippocampal synapses using molecular probes and optogenetic biosensors of exocytosis, Ca²⁺ dynamics and voltage. Changes in neural ensemble activity associated with these molecular mechanisms will be observed in vivo using fiber photometry. Opportunities also exist for experience in the electrophysiology and molecular biology of sodium channels.
Project two is to identify changes in ion channel expression and function that coincide with hyperexcitability in early neurodegeneration and the role of general anesthetics as novel inhibitors of neuronal excitability in neurodegeneration. Research strategies will explore the function of sodium channels in early Alzheimer’s Disease using molecular biological techniques combined with in vivo Ca²⁺ imaging by fiber photometry and behavioral studies in transgenic mouse models.
Job Requirements: Successful candidates must have a Ph.D. in neuroscience/neuropharmacology with experience in imaging including fluorescence microscopy, molecular biological techniques, cell culture, and rodent neuroanatomy. Proficiency in English is essential.
To Apply: Please send a brief letter of interest describing how your current experience, skills, and future goals align with either position, along with your CV and contact information for three references to Jimcy Platholi, Ph.D. (firstname.lastname@example.org).