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Interneuron diversity
Sodium channels as anesthetic targets
Volatile anesthetic effects on intracellular Ca2+ dynamics influence synaptic vesicle exocytosis
Volatile anesthetics directly bind Nav
Dr. Platholi's Research Projects
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Role of genetic polymorphisms in anesthetic-induced effects on synaptic function and structure.
Spine plasticity in anesthetic action
Voltage gated sodium channels (Nav) and hyperexcitability in early Alzheimer Disease.
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L
Lien CA
,
Hemmings HC
,
Belmont MR
,
Abalos A
,
Hollmann C
,
Kelly RE
. 1996.
A comparison: the efficacy of sevoflurane-nitrous oxide or propofol-nitrous oxide for the induction and maintenance of general anesthesia.
.
J Clin Anesth. 8(8):639-43.
Lingamaneni R
,
Hemmings HC
. 2003.
Differential interaction of anaesthetics and antiepileptic drugs with neuronal Na+ channels, Ca2+ channels, and GABA(A) receptors.
.
Br J Anaesth. 90(2):199-211.
Lingamaneni R
,
Hemmings HC
. 1999.
Effects of anticonvulsants on veratridine- and KCl-evoked glutamate release from rat cortical synaptosomes.
.
Neurosci Lett. 276(2):127-30.
Lingamaneni R
,
Krasowski MD
,
Jenkins A
,
Truong T
,
Giunta AL
,
Blackbeer J
,
MacIver MB
,
Harrison NL
,
Hemmings HC
. 2001.
Anesthetic properties of 4-iodopropofol: implications for mechanisms of anesthesia.
.
Anesthesiology. 94(6):1050-7.
Lingamaneni R
,
Birch ML
,
Hemmings HC
. 2001.
Widespread inhibition of sodium channel-dependent glutamate release from isolated nerve terminals by isoflurane and propofol.
.
Anesthesiology. 95(6):1460-6.
Lingameneni R
,
Vysotskaya TN
,
Duch DS
,
Hemmings HC
. 2000.
Inhibition of voltage-dependent sodium channels by Ro 31-8220, a 'specific' protein kinase C inhibitor.
.
FEBS Lett. 473(2):265-8.
M
Mantz J
,
Hemmings HC
. 2011.
Sleep and anesthesia: the histamine connection.
.
Anesthesiology. 115(1):8-9.
Mantz J
,
Hemmings HC
,
Boddaert J
. 2010.
Case scenario: postoperative delirium in elderly surgical patients.
.
Anesthesiology. 112(1):189-95.
Matovcik LM
,
Hemmings HC
,
Kinder BK
. 1995.
DARPP-32 (dopamine and cAMP-regulated phosphoprotein, M(r) 32,000) is a membrane protein in the bovine parathyroid.
.
FEBS Lett. 364(1):67-74.
Mayerhofer A
,
Hemmings HC
,
Snyder GL
,
Greengard P
,
Boddien S
,
Berg U
,
Brucker C
. 1999.
Functional dopamine-1 receptors and DARPP-32 are expressed in human ovary and granulosa luteal cells in vitro.
.
J Clin Endocrinol Metab. 84(1):257-64.
McAvoy T
,
Allen PB
,
Obaishi H
,
Nakanishi H
,
Takai Y
,
Greengard P
,
Nairn AC
,
Hemmings HC
. 1999.
Regulation of neurabin I interaction with protein phosphatase 1 by phosphorylation.
.
Biochemistry. 38(39):12943-9.
Meister B
,
Schultzberg M
,
Hemmings HC
,
Greengard P
,
Goldstein M
,
Hökfelt T
. 1991.
Dopamine- and adenosine-3',5'-monophosphate (cAMP)-regulated phosphoprotein of 32 kDa (DARPP-32) in the adrenal gland: immunohistochemical localization.
.
J Auton Nerv Syst. 36(1):75-84.
Meister B
,
Askergren J
,
Tunevall G
,
Hemmings HC
,
Greengard P
. 1991.
Identification of a dopamine- and 3'5'-cyclic adenosine monophosphate-regulated phosphoprotein of 32 kD (DARPP-32) in parathyroid hormone-producing cells of the human parathyroid gland.
.
J Endocrinol Invest. 14(8):655-61.
Meister B
,
Fried G
,
Hökfelt T
,
Hemmings HC
,
Greengard P
. 1988.
Immunohistochemical evidence for the existence of a dopamine- and cyclic AMP-regulated phosphoprotein (DARPP-32) in brown adipose tissue of pigs.
.
Proc Natl Acad Sci U S A. 85(22):8713-6.
Meister B
,
Arvidsson U
,
Hemmings HC
,
Greengard P
,
Hökfelt T
. 1991.
Dopamine- and adenosine-3':5'-monophosphate (cAMP)-regulated phosphoprotein of Mr 32,000 (DARPP-32) in the retina of cat, monkey and human.
.
Neurosci Lett. 131(1):66-70.
Meister B
,
Fryckstedt J
,
Schalling M
,
Cortés R
,
Hökfelt T
,
Aperia A
,
Hemmings HC
,
Nairn AC
,
Ehrlich M
,
Greengard P
. 1989.
Dopamine- and cAMP-regulated phosphoprotein (DARPP-32) and dopamine DA1 agonist-sensitive Na+,K+-ATPase in renal tubule cells.
.
Proc Natl Acad Sci U S A. 86(20):8068-72.
Morrow PW
,
Tung HYLim
,
Hemmings HC
. 2004.
Rapamycin causes activation of protein phosphatase-2A1 and nuclear translocation of PCNA in CD4+ T cells.
.
Biochem Biophys Res Commun. 323(2):645-51.
Murugaiah KD
,
Hemmings HC
. 1998.
Effects of intravenous general anesthetics on [3H]GABA release from rat cortical synaptosomes.
.
Anesthesiology. 89(4):919-28.
N
Nairn AC
,
Hemmings HC
,
Greengard P
. 1985.
Protein kinases in the brain.
.
Annu Rev Biochem. 54:931-76.
Nairn AC
,
Hemmings HC
,
Walaas SI
,
Greengard P
. 1988.
DARPP-32 and phosphatase inhibitor-1, two structurally related inhibitors of protein phosphatase-1, are both present in striatonigral neurons.
.
J Neurochem. 50(1):257-62.
New AS
,
Hazlett EA
,
Buchsbaum MS
,
Goodman M
,
Reynolds D
,
Mitropoulou V
,
Sprung L
,
Shaw RB
,
Koenigsberg H
,
Platholi J
et al.
. 2002.
Blunted prefrontal cortical 18fluorodeoxyglucose positron emission tomography response to meta-chlorophenylpiperazine in impulsive aggression.
.
Arch Gen Psychiatry. 59(7):621-9.
Nguyen C
,
Nishi A
,
Kansy JW
,
Fernandez J
,
Hayashi K
,
Gillardon F
,
Hemmings HC
,
Nairn AC
,
Bibb JA
. 2007.
Regulation of protein phosphatase inhibitor-1 by cyclin-dependent kinase 5.
.
J Biol Chem. 282(22):16511-20.
O
Osman V
,
Speigel I
,
Patel K
,
Hemmings HC
. 2023.
Isoflurane Alters Presynaptic Endoplasmic Reticulum Calcium Dynamics in Wild-Type and Malignant Hyperthermia-Susceptible Rodent Hippocampal Neurons.
.
eNeuro. 10(8)
Ouimet CC
,
Miller PE
,
Hemmings HC
,
Walaas SI
,
Greengard P
. 1984.
DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. III. Immunocytochemical localization.
.
J Neurosci. 4(1):111-24.
Ouimet CC
,
Hemmings HC
,
Greengard P
. 1989.
ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions. II. Immunocytochemical localization in rat brain.
.
J Neurosci. 9(3):865-75.
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