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Interneuron diversity
Sodium channels as anesthetic targets
Volatile anesthetic effects on intracellular Ca2+ dynamics influence synaptic vesicle exocytosis
Volatile anesthetics directly bind Nav
Dr. Platholi's Research Projects
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Role of genetic polymorphisms in anesthetic-induced effects on synaptic function and structure.
Spine plasticity in anesthetic action
Voltage gated sodium channels (Nav) and hyperexcitability in early Alzheimer Disease.
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Found 24 results
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1994
Hvalby O, Hemmings HC, Paulsen O, Czernik AJ, Nairn AC, Godfraind JM, Jensen V, Raastad M, Storm JF, Andersen P
. 1994.
Specificity of protein kinase inhibitor peptides and induction of long-term potentiation.
.
Proc Natl Acad Sci U S A. 91(11):4761-5.
1996
Ratnakumari L, Hemmings HC
. 1996.
Inhibition by propofol of [3H]-batrachotoxinin-A 20-alpha-benzoate binding to voltage-dependent sodium channels in rat cortical synaptosomes.
.
Br J Pharmacol. 119(7):1498-504.
1997
Ratnakumari L, Hemmings HC
. 1997.
Effects of propofol on sodium channel-dependent sodium influx and glutamate release in rat cerebrocortical synaptosomes.
.
Anesthesiology. 86(2):428-39.
1998
Ratnakumari L, Hemmings HC
. 1998.
Inhibition of presynaptic sodium channels by halothane.
.
Anesthesiology. 88(4):1043-54.
2000
Ratnakumari L, Vysotskaya TN, Duch DS, Hemmings HC
. 2000.
Differential effects of anesthetic and nonanesthetic cyclobutanes on neuronal voltage-gated sodium channels.
.
Anesthesiology. 92(2):529-41.
Caporaso GL, Bibb JA, Snyder GL, Valle C, Rakhilin S, Fienberg AA, Hemmings HC, Nairn AC, Greengard P
. 2000.
Drugs of abuse modulate the phosphorylation of ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in the basal ganglia.
.
Neuropharmacology. 39(9):1637-44.
2002
New AS, Hazlett EA, Buchsbaum MS, Goodman M, Reynolds D, Mitropoulou V, Sprung L, Shaw RB, Koenigsberg H, Platholi J et al.
. 2002.
Blunted prefrontal cortical 18fluorodeoxyglucose positron emission tomography response to meta-chlorophenylpiperazine in impulsive aggression.
.
Arch Gen Psychiatry. 59(7):621-9.
2005
Hemmings HC, Yan W, Westphalen RI, Ryan TA
. 2005.
The general anesthetic isoflurane depresses synaptic vesicle exocytosis.
.
Mol Pharmacol. 67(5):1591-9.
2006
Buchsbaum MS, Hollander E, Pallanti S, Rossi NBaldini, Platholi J, Newmark R, Bloom R, Sood E
. 2006.
Positron emission tomography imaging of risperidone augmentation in serotonin reuptake inhibitor-refractory patients.
.
Neuropsychobiology. 53(3):157-68.
2008
Eger EI, Raines DE, Shafer SL, Hemmings HC, Sonner JM
. 2008.
Is a new paradigm needed to explain how inhaled anesthetics produce immobility?
Anesth Analg. 107(3):832-48.
2010
Hemmings HC, Rosenberg AD, Reilly CS, Hunter JM
. 2010.
The 2010 BJA/PGA supplement: a selection of 10 educational reviews.
.
Br J Anaesth. 105 Suppl 1:i1-2.
Hemmings HC, Rosenberg AD, Reilly CS, Hunter JM
. 2010.
The 2010 BJA/PGA supplement: a selection of 10 educational reviews.
.
Br J Anaesth. 105 Suppl 1:i1-2.
2011
Rosenberg AD, Hemmings HC, Reilly CS, Webster NR
. 2011.
The 2011 BJA/PGA supplement: a selection of nine educational reviews.
.
Br J Anaesth. 107 Suppl 1:i1-2.
Rosenberg AD, Hemmings HC, Reilly CS, Webster NR
. 2011.
The 2011 BJA/PGA supplement: a selection of nine educational reviews.
.
Br J Anaesth. 107 Suppl 1:i1-2.
Rusinova R, Herold KF, R Sanford L, Greathouse DV, Hemmings HC, Andersen OS
. 2011.
Thiazolidinedione insulin sensitizers alter lipid bilayer properties and voltage-dependent sodium channel function: implications for drug discovery.
.
J Gen Physiol. 138(2):249-70.
2012
Hemmings HC, Rosenberg AD, Mahajan RP, Webster NR
. 2012.
The 2012 BJA/PGA supplement: a selection of seven educational reviews.
.
Br J Anaesth. 109 Suppl 1:i1-i2.
2013
Tibbs GR, Rowley TJ, R Sanford L, Herold KF, Proekt A, Hemmings HC, Andersen OS, Goldstein PA, Flood PD
. 2013.
HCN1 channels as targets for anesthetic and nonanesthetic propofol analogs in the amelioration of mechanical and thermal hyperalgesia in a mouse model of neuropathic pain.
.
J Pharmacol Exp Ther. 345(3):363-73.
2014
Ingólfsson HI, Thakur P, Herold KF, E Hobart A, Ramsey NB, Periole X, de Jong DH, Zwama M, Yilmaz D, Hall K et al.
. 2014.
Phytochemicals perturb membranes and promiscuously alter protein function.
.
ACS Chem Biol. 9(8):1788-98.
2015
Baumgart JP, Zhou Z-Y, Hara M, Cook DC, Hoppa MB, Ryan TA, Hemmings HC
. 2015.
Isoflurane inhibits synaptic vesicle exocytosis through reduced Ca2+ influx, not Ca2+-exocytosis coupling.
.
Proc Natl Acad Sci U S A. 112(38):11959-64.
2016
Riegelhaupt PM, Hemmings HC, Goldstein PA
. 2016.
Relevance of Clinical Relevance.
.
Anesthesiology. 125(4):821-2.
2019
Torturo CL, Zhou Z-Y, Ryan TA, Hemmings HC
. 2019.
Isoflurane Inhibits Dopaminergic Synaptic Vesicle Exocytosis Coupled to Ca2.1 and Ca2.2 in Rat Midbrain Neurons.
.
eNeuro. 6(1)
Hemmings HC, Riegelhaupt PM, Kelz MB, Solt K, Eckenhoff RG, Orser BA, Goldstein PA
. 2019.
Towards a Comprehensive Understanding of Anesthetic Mechanisms of Action: A Decade of Discovery.
.
Trends Pharmacol Sci. 40(7):464-481.
2023
Fitch W, Smith G, Hunter JM, Reilly CS, Mahajan RP, Hemmings HC
. 2023.
Corrigendum to 'The evolution of the British Journal of Anaesthesia: the first 100 years' [Br J Anaesth 2023; 130: 3-7].
.
Br J Anaesth. 130(4):495.
Fitch W, Smith G, Hunter JM, Reilly CS, Mahajan RP, Hemmings HC
. 2023.
The evolution of the British Journal of Anaesthesia: the first 100 years.
.
Br J Anaesth. 130(1):3-7.