| Title | Identification of a dopamine- and 3'5'-cyclic adenosine monophosphate-regulated phosphoprotein of 32 kD (DARPP-32) in parathyroid hormone-producing cells of the human parathyroid gland. |
| Publication Type | Journal Article |
| Year of Publication | 1991 |
| Authors | Meister B, Askergren J, Tunevall G, Hemmings HC, Greengard P |
| Journal | J Endocrinol Invest |
| Volume | 14 |
| Issue | 8 |
| Pagination | 655-61 |
| Date Published | 1991 Sep |
| ISSN | 0391-4097 |
| Keywords | Adenoma, Cyclic AMP, Dopamine, Dopamine and cAMP-Regulated Phosphoprotein 32, Fluorescent Antibody Technique, Humans, Molecular Weight, Nerve Tissue Proteins, Parathyroid Glands, Parathyroid Hormone, Parathyroid Neoplasms, Phosphoproteins |
| Abstract | The cellular localization of DARPP-32, a dopamine- and cyclic AMP-regulated phosphoprotein of 32 kD, enriched in dopamine-innervated brain regions, was investigated in the human parathyroid gland using indirect immunofluorescence histochemistry. Monoclonal antibodies were used to demonstrate DARPP-32-like immunoreactivity (LI) in chief cells of the normal human parathyroid gland and in cells of human parathyroid adenoma. Direct double-labelling revealed coexistence of DARPP-32-LI with parathyroid hormone (PTH)-LI. It has previously been demonstrated that dopamine D1-receptors are present in the parathyroid gland and that dopamine and D1-agonists stimulate the release of PTH. The present results suggest that DARPP-32 may play a role in the cellular mechanisms leading to dopamine-induced PTH secretion. |
| DOI | 10.1007/BF03347888 |
| Alternate Journal | J Endocrinol Invest |
| PubMed ID | 1663529 |
| Grant List | MH40899 / MH / NIMH NIH HHS / United States MH43230 / MH / NIMH NIH HHS / United States |