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Interneuron diversity
Sodium channels as anesthetic targets
Volatile anesthetic effects on intracellular Ca2+ dynamics influence synaptic vesicle exocytosis
Volatile anesthetics directly bind Nav
Dr. Platholi's Research Projects
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Role of genetic polymorphisms in anesthetic-induced effects on synaptic function and structure.
Spine plasticity in anesthetic action
Voltage gated sodium channels (Nav) and hyperexcitability in early Alzheimer Disease.
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Title
Type
Year
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X
Y
Z
H
Hemmings HC
,
Adamo AI
. 1997.
Effect of halothane on conventional protein kinase C translocation and down-regulation in rat cerebrocortical synaptosomes.
.
Br J Anaesth. 78(2):189-96.
Hemmings HC
,
Greengard P
. 1986.
DARPP-32, a dopamine-regulated phosphoprotein.
.
Prog Brain Res. 69:149-59.
Hemmings HC
,
Antognini JF
. 2006.
Do general anesthetics add up?
Anesthesiology. 104(6):1120-2.
Hemmings HC
,
Wlody D
,
Mahajan R
,
Webster NR
. 2013.
2013 BJA/PGA Special Issue: a selection of nine educational reviews.
.
Br J Anaesth. 111 Suppl 1:i1-2.
Hemmings HC
,
Nairn AC
,
Elliott JI
,
Greengard P
. 1990.
Synthetic peptide analogs of DARPP-32 (Mr 32,000 dopamine- and cAMP-regulated phosphoprotein), an inhibitor of protein phosphatase-1. Phosphorylation, dephosphorylation, and inhibitory activity.
.
J Biol Chem. 265(33):20369-76.
Hemmings HC
,
Rosenberg AD
,
Mahajan RP
,
Webster NR
. 2012.
The 2012 BJA/PGA supplement: a selection of seven educational reviews.
.
Br J Anaesth. 109 Suppl 1:i1-i2.
Hemmings HC
,
Nairn AC
,
Aswad DW
,
Greengard P
. 1984.
DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. II. Purification and characterization of the phosphoprotein from bovine caudate nucleus.
.
J Neurosci. 4(1):99-110.
Hazlett EA
,
Buchsbaum MS
,
Hsieh P
,
M Haznedar M
,
Platholi J
,
LiCalzi EM
,
Cartwright C
,
Hollander E
. 2004.
Regional glucose metabolism within cortical Brodmann areas in healthy individuals and autistic patients.
.
Neuropsychobiology. 49(3):115-25.
Hazlett EA
,
Buchsbaum MS
,
Kemether E
,
Bloom R
,
Platholi J
,
Brickman AM
,
Shihabuddin L
,
Tang C
,
Byne W
. 2004.
Abnormal glucose metabolism in the mediodorsal nucleus of the thalamus in schizophrenia.
.
Am J Psychiatry. 161(2):305-14.
Hara M
,
Zhou Z-Y
,
Hemmings HC
. 2016.
α2-Adrenergic Receptor and Isoflurane Modulation of Presynaptic Ca2+ Influx and Exocytosis in Hippocampal Neurons.
.
Anesthesiology. 125(3):535-46.
G
Gustafson EL
,
Girault JA
,
Hemmings HC
,
Nairn AC
,
Greengard P
. 1991.
Immunocytochemical localization of phosphatase inhibitor-1 in rat brain.
.
J Comp Neurol. 310(2):170-88.
Glausier JR
,
Maddox M
,
Hemmings HC
,
Nairn AC
,
Greengard P
,
Muly EC
. 2010.
Localization of dopamine- and cAMP-regulated phosphoprotein-32 and inhibitor-1 in area 9 of Macaca mulatta prefrontal cortex.
.
Neuroscience. 167(2):428-38.
Girault JA
,
Walaas SI
,
Hemmings HC
,
Greengard P
. 1990.
ARPP-21, a cAMP-regulated phosphoprotein enriched in dopamine-innervated brain regions: tissue distribution and regulation of phosphorylation in rat brain.
.
Neuroscience. 37(2):317-25.
Girault JA
,
Hemmings HC
,
Zorn SH
,
Gustafson EL
,
Greengard P
. 1990.
Characterization in mammalian brain of a DARPP-32 serine kinase identical to casein kinase II.
.
J Neurochem. 55(5):1772-83.
Girault JA
,
Hemmings HC
,
Williams KR
,
Nairn AC
,
Greengard P
. 1989.
Phosphorylation of DARPP-32, a dopamine- and cAMP-regulated phosphoprotein, by casein kinase II.
.
J Biol Chem. 264(36):21748-59.
Giambrone GP
,
Hemmings HC
,
Sturm M
,
Fleischut PM
. 2015.
Information technology innovation: the power and perils of big data.
.
Br J Anaesth. 115(3):339-42.
F
Futter M
,
Uematsu K
,
Bullock SA
,
Kim Y
,
Hemmings HC
,
Nishi A
,
Greengard P
,
Nairn AC
. 2005.
Phosphorylation of spinophilin by ERK and cyclin-dependent PK 5 (Cdk5).
.
Proc Natl Acad Sci U S A. 102(9):3489-94.
Fu D
,
Vissavajjhala P
,
Hemmings HC
. 2005.
Volatile anaesthetic effects on phospholipid binding to synaptotagmin 1, a presynaptic Ca2+ sensor.
.
Br J Anaesth. 95(2):216-21.
Foster GA
,
Schultzberg M
,
Kökfelt T
,
Goldstein M
,
Hemmings HC
,
Ouimet CC
,
Walaas SI
,
Greengard P
. 1988.
Ontogeny of the dopamine and cyclic adenosine-3':5'-monophosphate-regulated phosphoprotein (DARPP-32) in the pre- and postnatal mouse central nervous system.
.
Int J Dev Neurosci. 6(4):367-86.
Foster GA
,
Schultzberg M
,
Hökfelt T
,
Goldstein M
,
Hemmings HC
,
Ouimet CC
,
Walaas SI
,
Greengard P
. 1987.
Development of a dopamine- and cyclic adenosine 3':5'-monophosphate-regulated phosphoprotein (DARPP-32) in the prenatal rat central nervous system, and its relationship to the arrival of presumptive dopaminergic innervation.
.
J Neurosci. 7(7):1994-2018.
Fitch W
,
Smith G
,
Hunter JM
,
Reilly CS
,
Mahajan RP
,
Hemmings HC
. 2023.
The evolution of the British Journal of Anaesthesia: the first 100 years.
.
Br J Anaesth. 130(1):3-7.
Fitch W
,
Smith G
,
Hunter JM
,
Reilly CS
,
Mahajan RP
,
Hemmings HC
. 2023.
Corrigendum to 'The evolution of the British Journal of Anaesthesia: the first 100 years' [Br J Anaesth 2023; 130: 3-7].
.
Br J Anaesth. 130(4):495.
Fisone G
,
Cheng SX
,
Nairn AC
,
Czernik AJ
,
Hemmings HC
,
Höög JO
,
Bertorello AM
,
Kaiser R
,
Bergman T
,
Jörnvall H
. 1994.
Identification of the phosphorylation site for cAMP-dependent protein kinase on Na+,K(+)-ATPase and effects of site-directed mutagenesis.
.
J Biol Chem. 269(12):9368-73.
E
Eger EI
,
Raines DE
,
Shafer SL
,
Hemmings HC
,
Sonner JM
. 2008.
Is a new paradigm needed to explain how inhaled anesthetics produce immobility?
Anesth Analg. 107(3):832-48.
D
Durstewitz D
,
Kröner S
,
Hemmings HC
,
Güntürkün O
. 1998.
The dopaminergic innervation of the pigeon telencephalon: distribution of DARPP-32 and co-occurrence with glutamate decarboxylase and tyrosine hydroxylase.
.
Neuroscience. 83(3):763-79.
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