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Interneuron diversity
Sodium channels as anesthetic targets
Volatile anesthetic effects on intracellular Ca2+ dynamics influence synaptic vesicle exocytosis
Volatile anesthetics directly bind Nav
Dr. Platholi's Research Projects
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Role of genetic polymorphisms in anesthetic-induced effects on synaptic function and structure.
Spine plasticity in anesthetic action
Voltage gated sodium channels (Nav) and hyperexcitability in early Alzheimer Disease.
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W
Westphalen RI
,
Yu J
,
Krivitski M
,
Jih T-Y
,
Hemmings HC
. 2010.
Regional differences in nerve terminal Na+ channel subtype expression and Na+ channel-dependent glutamate and GABA release in rat CNS.
.
J Neurochem. 113(6):1611-20.
Westphalen RI
,
Hemmings HC
. 2006.
Volatile anesthetic effects on glutamate versus GABA release from isolated rat cortical nerve terminals: 4-aminopyridine-evoked release.
.
J Pharmacol Exp Ther. 316(1):216-23.
Westphalen RI
,
Desai KM
,
Hemmings HC
. 2013.
Presynaptic inhibition of the release of multiple major central nervous system neurotransmitter types by the inhaled anaesthetic isoflurane.
.
Br J Anaesth. 110(4):592-9.
Westphalen RI
,
Hemmings HC
. 2006.
Volatile anesthetic effects on glutamate versus GABA release from isolated rat cortical nerve terminals: basal release.
.
J Pharmacol Exp Ther. 316(1):208-15.
Westphalen RI
,
Krivitski M
,
Amarosa A
,
Guy N
,
Hemmings HC
. 2007.
Reduced inhibition of cortical glutamate and GABA release by halothane in mice lacking the K+ channel, TREK-1.
.
Br J Pharmacol. 152(6):939-45.
Williams KR
,
Hemmings HC
,
LoPresti MB
,
Konigsberg WH
,
Greengard P
. 1986.
DARPP-32, a dopamine- and cyclic AMP-regulated neuronal phosphoprotein. Primary structure and homology with protein phosphatase inhibitor-1.
.
J Biol Chem. 261(4):1890-903.
Williams RA
,
Johnson KW
,
Lee FS
,
Hemmings HC
,
Platholi J
. 2022.
A Common Human Brain-Derived Neurotrophic Factor Polymorphism Leads to Prolonged Depression of Excitatory Synaptic Transmission by Isoflurane in Hippocampal Cultures.
.
Front Mol Neurosci. 15:927149.
Williams KR
,
Hemmings HC
,
LoPresti MB
,
Greengard P
. 1989.
ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions. I. Amino acid sequence of ARPP-21B from bovine caudate nucleus.
.
J Neurosci. 9(10):3631-7.
Wong CA
,
S Moonesinghe R
,
Boer C
,
Hemmings HC
,
Hunter JM
. 2020.
Women in anaesthesia, a special issue of the British Journal of Anaesthesia.
.
Br J Anaesth. 124(3):e40-e43.
Y
Yun S-W
,
Platholi J
,
Flaherty MSol
,
Fu W
,
Kottmann AH
,
Toth M
. 2006.
Fmrp is required for the establishment of the startle response during the critical period of auditory development.
.
Brain Res. 1110(1):159-65.
Z
Zhang TT
,
Platholi J
,
Heerdt PM
,
Hemmings HC
,
Tung HYL
. 2008.
Protein phosphatase-2A is activated in pig brain following cardiac arrest and resuscitation.
.
Metab Brain Dis. 23(1):95-104.
Zhang Y
,
Sharma M
,
Eger EI
,
Laster MJ
,
Hemmings HC
,
R Harris A
. 2008.
Intrathecal veratridine administration increases minimum alveolar concentration in rats.
.
Anesth Analg. 107(3):875-8.
Zhang Y
,
Guzinski M
,
Eger EI
,
Laster MJ
,
Sharma M
,
Harris RA
,
Hemmings HC
. 2010.
Bidirectional modulation of isoflurane potency by intrathecal tetrodotoxin and veratridine in rats.
.
Br J Pharmacol. 159(4):872-8.
Zhao W
,
Zhang M
,
Liu J
,
Liang P
,
Wang R
,
Hemmings HC
,
Zhou C
. 2019.
Isoflurane Modulates Hippocampal Cornu Ammonis Pyramidal Neuron Excitability by Inhibition of Both Transient and Persistent Sodium Currents in Mice.
.
Anesthesiology. 131(1):94-104.
Zhao W
,
Zhao S
,
Zhu T
,
Ou M
,
Zhang D
,
Sun H
,
Liu J
,
Chen X
,
Hemmings HC
,
Zhou C
. 2021.
Isoflurane Suppresses Hippocampal High-frequency Ripples by Differentially Modulating Pyramidal Neurons and Interneurons in Mice.
.
Anesthesiology. 135(1):122-135.
Zhou C
,
Johnson KW
,
Herold KF
,
Hemmings HC
. 2019.
Differential Inhibition of Neuronal Sodium Channel Subtypes by the General Anesthetic Isoflurane.
.
J Pharmacol Exp Ther. 369(2):200-211.
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