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Interneuron diversity
Sodium channels as anesthetic targets
Volatile anesthetic effects on intracellular Ca2+ dynamics influence synaptic vesicle exocytosis
Volatile anesthetics directly bind Nav
Dr. Platholi's Research Projects
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Role of genetic polymorphisms in anesthetic-induced effects on synaptic function and structure.
Spine plasticity in anesthetic action
Voltage gated sodium channels (Nav) and hyperexcitability in early Alzheimer Disease.
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Y
Z
A
Absil P
,
Foidart A
,
Hemmings HC
,
Steinbusch HW
,
Ball GF
,
Balthazart J
. 2001.
Distribution of DARPP-32 immunoreactive structures in the quail brain: anatomical relationship with dopamine and aromatase.
.
J Chem Neuroanat. 21(1):23-39.
Agnati LF
,
Fuxe K
,
Zoli M
,
Ferraguti F
,
Benfenati F
,
Ouimet CC
,
Walaas SI
,
Hemmings HC
,
Goldstein M
,
Greengard P
. 1988.
Morphometrical evidence for a complex organization of tyrosine hydroxylase-, enkephalin- and DARPP-32-like immunoreactive patches and their codistribution at three rostrocaudal levels in the rat neostriatum.
.
Neuroscience. 27(3):785-97.
Albert KA
,
Hemmings HC
,
Adamo AIB
,
Potkin SG
,
Akbarian S
,
Sandman CA
,
Cotman CW
,
Bunney WE
,
Greengard P
. 2002.
Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophrenia.
.
Arch Gen Psychiatry. 59(8):705-12.
Aperia A
,
Fryckstedt J
,
Svensson L
,
Hemmings HC
,
Nairn AC
,
Greengard P
. 1991.
Phosphorylated Mr 32,000 dopamine- and cAMP-regulated phosphoprotein inhibits Na+,K(+)-ATPase activity in renal tubule cells.
.
Proc Natl Acad Sci U S A. 88(7):2798-801.
Asai T
,
O'Sullivan EP
,
Hemmings HC
. 2020.
A special issue on respiration and the airway: critical topics at a challenging time.
.
Br J Anaesth. 125(1):1-4.
B
Bálint E
,
Kitka T
,
Zachar G
,
Adám A
,
Hemmings HC
,
Csillag A
. 2004.
Abundance and location of DARPP-32 in striato-tegmental circuits of domestic chicks.
.
J Chem Neuroanat. 28(1-2):27-36.
Baumgart JP
,
Zhou Z-Y
,
Hara M
,
Cook DC
,
Hoppa MB
,
Ryan TA
,
Hemmings HC
. 2015.
Isoflurane inhibits synaptic vesicle exocytosis through reduced Ca2+ influx, not Ca2+-exocytosis coupling.
.
Proc Natl Acad Sci U S A. 112(38):11959-64.
Bendor J
,
Lizardi-Ortiz JE
,
Westphalen RI
,
Brandstetter M
,
Hemmings HC
,
Sulzer D
,
Flajolet M
,
Greengard P
. 2010.
AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release.
.
EMBO J. 29(16):2813-26.
Bibb JA
,
Snyder GL
,
Nishi A
,
Yan Z
,
Meijer L
,
Fienberg AA
,
Tsai LH
,
Kwon YT
,
Girault JA
,
Czernik AJ
et al.
. 1999.
Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons.
.
Nature. 402(6762):669-71.
Bruening S
,
Oh E
,
Hetzenauer A
,
Escobar-Alvarez S
,
Westphalen RI
,
Hemmings HC
,
Singewald N
,
Shippenberg T
,
Toth M
. 2006.
The anxiety-like phenotype of 5-HT receptor null mice is associated with genetic background-specific perturbations in the prefrontal cortex GABA-glutamate system.
.
J Neurochem. 99(3):892-9.
Buchsbaum MS
,
Hollander E
,
Pallanti S
,
Rossi NBaldini
,
Platholi J
,
Newmark R
,
Bloom R
,
Sood E
. 2006.
Positron emission tomography imaging of risperidone augmentation in serotonin reuptake inhibitor-refractory patients.
.
Neuropsychobiology. 53(3):157-68.
Buggy DJ
,
Borgeat A
,
Cata J
,
Doherty DG
,
Doornebal CW
,
Forget P
,
Gottumukkala V
,
Gottschalk A
,
Gupta A
,
Gupta K
et al.
. 2015.
Consensus statement from the BJA Workshop on Cancer and Anaesthesia.
.
Br J Anaesth. 114(1):2-3.
Buggy DJ
,
Hemmings HC
. 2014.
Special issue on anaesthesia and cancer.
.
Br J Anaesth. 113 Suppl 1:i1-3.
S Bullock A
,
Platholi J
,
Gjyrezi A
,
Heerdt PM
,
Tung HYLim
,
Hemmings HC
. 2007.
Differential regulation of protein phosphatase-1(I) by neurabin.
.
Biochem Biophys Res Commun. 358(1):140-4.
C
Caporaso GL
,
Bibb JA
,
Snyder GL
,
Valle C
,
Rakhilin S
,
Fienberg AA
,
Hemmings HC
,
Nairn AC
,
Greengard P
. 2000.
Drugs of abuse modulate the phosphorylation of ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in the basal ganglia.
.
Neuropharmacology. 39(9):1637-44.
Chang S
,
Hemmings HC
,
Aderem A
. 1996.
Stimulus-dependent phosphorylation of MacMARCKS, a protein kinase C substrate, in nerve termini and PC12 cells.
.
J Biol Chem. 271(2):1174-8.
D
Durstewitz D
,
Kröner S
,
Hemmings HC
,
Güntürkün O
. 1998.
The dopaminergic innervation of the pigeon telencephalon: distribution of DARPP-32 and co-occurrence with glutamate decarboxylase and tyrosine hydroxylase.
.
Neuroscience. 83(3):763-79.
E
Eger EI
,
Raines DE
,
Shafer SL
,
Hemmings HC
,
Sonner JM
. 2008.
Is a new paradigm needed to explain how inhaled anesthetics produce immobility?
Anesth Analg. 107(3):832-48.
F
Fisone G
,
Cheng SX
,
Nairn AC
,
Czernik AJ
,
Hemmings HC
,
Höög JO
,
Bertorello AM
,
Kaiser R
,
Bergman T
,
Jörnvall H
. 1994.
Identification of the phosphorylation site for cAMP-dependent protein kinase on Na+,K(+)-ATPase and effects of site-directed mutagenesis.
.
J Biol Chem. 269(12):9368-73.
Fitch W
,
Smith G
,
Hunter JM
,
Reilly CS
,
Mahajan RP
,
Hemmings HC
. 2023.
The evolution of the British Journal of Anaesthesia: the first 100 years.
.
Br J Anaesth. 130(1):3-7.
Fitch W
,
Smith G
,
Hunter JM
,
Reilly CS
,
Mahajan RP
,
Hemmings HC
. 2023.
Corrigendum to 'The evolution of the British Journal of Anaesthesia: the first 100 years' [Br J Anaesth 2023; 130: 3-7].
.
Br J Anaesth. 130(4):495.
Foster GA
,
Schultzberg M
,
Kökfelt T
,
Goldstein M
,
Hemmings HC
,
Ouimet CC
,
Walaas SI
,
Greengard P
. 1988.
Ontogeny of the dopamine and cyclic adenosine-3':5'-monophosphate-regulated phosphoprotein (DARPP-32) in the pre- and postnatal mouse central nervous system.
.
Int J Dev Neurosci. 6(4):367-86.
Foster GA
,
Schultzberg M
,
Hökfelt T
,
Goldstein M
,
Hemmings HC
,
Ouimet CC
,
Walaas SI
,
Greengard P
. 1987.
Development of a dopamine- and cyclic adenosine 3':5'-monophosphate-regulated phosphoprotein (DARPP-32) in the prenatal rat central nervous system, and its relationship to the arrival of presumptive dopaminergic innervation.
.
J Neurosci. 7(7):1994-2018.
Fu D
,
Vissavajjhala P
,
Hemmings HC
. 2005.
Volatile anaesthetic effects on phospholipid binding to synaptotagmin 1, a presynaptic Ca2+ sensor.
.
Br J Anaesth. 95(2):216-21.
Futter M
,
Uematsu K
,
Bullock SA
,
Kim Y
,
Hemmings HC
,
Nishi A
,
Greengard P
,
Nairn AC
. 2005.
Phosphorylation of spinophilin by ERK and cyclin-dependent PK 5 (Cdk5).
.
Proc Natl Acad Sci U S A. 102(9):3489-94.
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