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Interneuron diversity
Sodium channels as anesthetic targets
Volatile anesthetic effects on intracellular Ca2+ dynamics influence synaptic vesicle exocytosis
Volatile anesthetics directly bind Nav
Dr. Platholi's Research Projects
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Role of genetic polymorphisms in anesthetic-induced effects on synaptic function and structure.
Spine plasticity in anesthetic action
Voltage gated sodium channels (Nav) and hyperexcitability in early Alzheimer Disease.
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Author
Title
Type
Year
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U
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C
Buggy DJ
,
Borgeat A
,
Cata J
,
Doherty DG
,
Doornebal CW
,
Forget P
,
Gottumukkala V
,
Gottschalk A
,
Gupta A
,
Gupta K
et al.
. 2015.
Consensus statement from the BJA Workshop on Cancer and Anaesthesia.
.
Br J Anaesth. 114(1):2-3.
Lien CA
,
Hemmings HC
,
Belmont MR
,
Abalos A
,
Hollmann C
,
Kelly RE
. 1996.
A comparison: the efficacy of sevoflurane-nitrous oxide or propofol-nitrous oxide for the induction and maintenance of general anesthesia.
.
J Clin Anesth. 8(8):639-43.
OuYang W
,
Herold KF
,
Hemmings HC
. 2009.
Comparative effects of halogenated inhaled anesthetics on voltage-gated Na+ channel function.
.
Anesthesiology. 110(3):582-90.
Williams RA
,
Johnson KW
,
Lee FS
,
Hemmings HC
,
Platholi J
. 2022.
A Common Human Brain-Derived Neurotrophic Factor Polymorphism Leads to Prolonged Depression of Excitatory Synaptic Transmission by Isoflurane in Hippocampal Cultures.
.
Front Mol Neurosci. 15:927149.
Herold KF
,
R Sanford L
,
Lee W
,
Andersen OS
,
Hemmings HC
. 2017.
Clinical concentrations of chemically diverse general anesthetics minimally affect lipid bilayer properties.
.
Proc Natl Acad Sci U S A. 114(12):3109-3114.
Kaur G
,
Weinberg R
,
Milewski ARobert
,
Huynh S
,
Mauer E
,
Hemmings HCarroll
,
Pryor KOwen
. 2020.
Chronic pain diagnosis in refugee torture survivors: A prospective, blinded diagnostic accuracy study.
.
PLoS Med. 17(6):e1003108.
Wei L
,
Schlame M
,
Downes H
,
Hemmings HC
. 1996.
CHEB, a convulsant barbiturate, evokes calcium-dependent spontaneous glutamate release from rat cerebrocortical synaptosomes.
.
Neuropharmacology. 35(6):695-701.
Girault JA
,
Hemmings HC
,
Zorn SH
,
Gustafson EL
,
Greengard P
. 1990.
Characterization in mammalian brain of a DARPP-32 serine kinase identical to casein kinase II.
.
J Neurochem. 55(5):1772-83.
Hemmings HC
. 2019.
Change management: the British Journal of Anaesthesia in 2018.
.
Br J Anaesth. 122(1):1-3.
Hemmings HC
,
Lambert DG
. 2023.
Celebrating the first centenary of the British Journal of Anaesthesia: a century of discovery and dissemination.
.
Br J Anaesth. 130(1):1-2.
Mantz J
,
Hemmings HC
,
Boddaert J
. 2010.
Case scenario: postoperative delirium in elderly surgical patients.
.
Anesthesiology. 112(1):189-95.
B
New AS
,
Hazlett EA
,
Buchsbaum MS
,
Goodman M
,
Reynolds D
,
Mitropoulou V
,
Sprung L
,
Shaw RB
,
Koenigsberg H
,
Platholi J
et al.
. 2002.
Blunted prefrontal cortical 18fluorodeoxyglucose positron emission tomography response to meta-chlorophenylpiperazine in impulsive aggression.
.
Arch Gen Psychiatry. 59(7):621-9.
Hemmings HC
,
Adamo AI
,
Hoffman MM
. 1995.
Biochemical characterization of the stimulatory effects of halothane and propofol on purified brain protein kinase C.
.
Anesth Analg. 81(6):1216-22.
Perouansky M
,
Hemmings HC
. 2018.
Bioblasts, anaesthesia, and power failure: rein in the excitement.
.
Br J Anaesth. 120(5):891-895.
Zhang Y
,
Guzinski M
,
Eger EI
,
Laster MJ
,
Sharma M
,
Harris RA
,
Hemmings HC
. 2010.
Bidirectional modulation of isoflurane potency by intrathecal tetrodotoxin and veratridine in rats.
.
Br J Pharmacol. 159(4):872-8.
Walaas SIvar
,
Hemmings HCaroll
,
Greengard P
,
Nairn AClark
. 2011.
Beyond the dopamine receptor: regulation and roles of serine/threonine protein phosphatases.
.
Front Neuroanat. 5:50.
Perouansky M
,
Hemmings HC
. 2009.
Between Clotho and Lachesis: how isoflurane seals neuronal fate.
.
Anesthesiology. 110(4):709-11.
A
Hemmings HC
,
Girault JA
,
Williams KR
,
LoPresti MB
,
Greengard P
. 1989.
ARPP-21, a cyclic AMP-regulated phosphoprotein (Mr = 21,000) enriched in dopamine-innervated brain regions. Amino acid sequence of the site phosphorylated by cyclic AMP in intact cells and kinetic studies of its phosphorylation in vitro.
.
J Biol Chem. 264(13):7726-33.
Ouimet CC
,
Hemmings HC
,
Greengard P
. 1989.
ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions. II. Immunocytochemical localization in rat brain.
.
J Neurosci. 9(3):865-75.
Hemmings HC
,
Greengard P
. 1989.
ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions. I. Purification and characterization of the protein from bovine caudate nucleus.
.
J Neurosci. 9(3):851-64.
Williams KR
,
Hemmings HC
,
LoPresti MB
,
Greengard P
. 1989.
ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions. I. Amino acid sequence of ARPP-21B from bovine caudate nucleus.
.
J Neurosci. 9(10):3631-7.
Girault JA
,
Walaas SI
,
Hemmings HC
,
Greengard P
. 1990.
ARPP-21, a cAMP-regulated phosphoprotein enriched in dopamine-innervated brain regions: tissue distribution and regulation of phosphorylation in rat brain.
.
Neuroscience. 37(2):317-25.
Hudson AE
,
Hemmings HC
. 2011.
Are anaesthetics toxic to the brain?
Br J Anaesth. 107(1):30-7.
Bruening S
,
Oh E
,
Hetzenauer A
,
Escobar-Alvarez S
,
Westphalen RI
,
Hemmings HC
,
Singewald N
,
Shippenberg T
,
Toth M
. 2006.
The anxiety-like phenotype of 5-HT receptor null mice is associated with genetic background-specific perturbations in the prefrontal cortex GABA-glutamate system.
.
J Neurochem. 99(3):892-9.
Lingamaneni R
,
Krasowski MD
,
Jenkins A
,
Truong T
,
Giunta AL
,
Blackbeer J
,
MacIver MB
,
Harrison NL
,
Hemmings HC
. 2001.
Anesthetic properties of 4-iodopropofol: implications for mechanisms of anesthesia.
.
Anesthesiology. 94(6):1050-7.
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