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Interneuron diversity
Sodium channels as anesthetic targets
Volatile anesthetic effects on intracellular Ca2+ dynamics influence synaptic vesicle exocytosis
Volatile anesthetics directly bind Nav
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Role of genetic polymorphisms in anesthetic-induced effects on synaptic function and structure.
Spine plasticity in anesthetic action
Voltage gated sodium channels (Nav) and hyperexcitability in early Alzheimer Disease.
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Found 13 results
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Herold, Karl F
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C
Herold KF
,
R Sanford L
,
Lee W
,
Andersen OS
,
Hemmings HC
. 2017.
Clinical concentrations of chemically diverse general anesthetics minimally affect lipid bilayer properties.
.
Proc Natl Acad Sci U S A. 114(12):3109-3114.
OuYang W
,
Herold KF
,
Hemmings HC
. 2009.
Comparative effects of halogenated inhaled anesthetics on voltage-gated Na+ channel function.
.
Anesthesiology. 110(3):582-90.
D
Zhou C
,
Johnson KW
,
Herold KF
,
Hemmings HC
. 2019.
Differential Inhibition of Neuronal Sodium Channel Subtypes by the General Anesthetic Isoflurane.
.
J Pharmacol Exp Ther. 369(2):200-211.
Herold KF
,
Andersen OS
,
Hemmings HC
. 2017.
Divergent effects of anesthetics on lipid bilayer properties and sodium channel function.
.
Eur Biophys J. 46(7):617-626.
H
Tibbs GR
,
Rowley TJ
,
R Sanford L
,
Herold KF
,
Proekt A
,
Hemmings HC
,
Andersen OS
,
Goldstein PA
,
Flood PD
. 2013.
HCN1 channels as targets for anesthetic and nonanesthetic propofol analogs in the amelioration of mechanical and thermal hyperalgesia in a mouse model of neuropathic pain.
.
J Pharmacol Exp Ther. 345(3):363-73.
I
Herold KF
,
Nau C
,
OuYang W
,
Hemmings HC
. 2009.
Isoflurane inhibits the tetrodotoxin-resistant voltage-gated sodium channel Nav1.8.
.
Anesthesiology. 111(3):591-9.
Sand RM
,
Gingrich KJ
,
Macharadze T
,
Herold KF
,
Hemmings HC
. 2017.
Isoflurane modulates activation and inactivation gating of the prokaryotic Na channel NaChBac.
.
J Gen Physiol. 149(6):623-638.
Platholi J
,
Herold KF
,
Hemmings HC
,
Halpain S
. 2014.
Isoflurane reversibly destabilizes hippocampal dendritic spines by an actin-dependent mechanism.
.
PLoS One. 9(7):e102978.
P
Ingólfsson HI
,
Thakur P
,
Herold KF
,
E Hobart A
,
Ramsey NB
,
Periole X
,
de Jong DH
,
Zwama M
,
Yilmaz D
,
Hall K
et al.
. 2014.
Phytochemicals perturb membranes and promiscuously alter protein function.
.
ACS Chem Biol. 9(8):1788-98.
S
Johnson KW
,
Herold KF
,
Milner TA
,
Hemmings HC
,
Platholi J
. 2017.
Sodium channel subtypes are differentially localized to pre- and post-synaptic sites in rat hippocampus.
.
J Comp Neurol. 525(16):3563-3578.
Herold KF
,
Hemmings HC
. 2012.
Sodium channels as targets for volatile anesthetics.
.
Front Pharmacol. 3:50.
T
Rusinova R
,
Herold KF
,
R Sanford L
,
Greathouse DV
,
Hemmings HC
,
Andersen OS
. 2011.
Thiazolidinedione insulin sensitizers alter lipid bilayer properties and voltage-dependent sodium channel function: implications for drug discovery.
.
J Gen Physiol. 138(2):249-70.
V
Herold KF
,
R Sanford L
,
Lee W
,
Schultz MF
,
Ingólfsson HI
,
Andersen OS
,
Hemmings HC
. 2014.
Volatile anesthetics inhibit sodium channels without altering bulk lipid bilayer properties.
.
J Gen Physiol. 144(6):545-60.