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Interneuron diversity
Sodium channels as anesthetic targets
Volatile anesthetic effects on intracellular Ca2+ dynamics influence synaptic vesicle exocytosis
Volatile anesthetics directly bind Nav
Dr. Platholi's Research Projects
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Role of genetic polymorphisms in anesthetic-induced effects on synaptic function and structure.
Spine plasticity in anesthetic action
Voltage gated sodium channels (Nav) and hyperexcitability in early Alzheimer Disease.
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D
Herold KF
,
Andersen OS
,
Hemmings HC
. 2017.
Divergent effects of anesthetics on lipid bilayer properties and sodium channel function.
.
Eur Biophys J. 46(7):617-626.
Hemmings HC
,
Girault JA
,
Nairn AC
,
Bertuzzi G
,
Greengard P
. 1992.
Distribution of protein phosphatase inhibitor-1 in brain and peripheral tissues of various species: comparison with DARPP-32.
.
J Neurochem. 59(3):1053-61.
Absil P
,
Foidart A
,
Hemmings HC
,
Steinbusch HW
,
Ball GF
,
Balthazart J
. 2001.
Distribution of DARPP-32 immunoreactive structures in the quail brain: anatomical relationship with dopamine and aromatase.
.
J Chem Neuroanat. 21(1):23-39.
Ouyang W
,
Wang G
,
Hemmings HC
. 2004.
Distinct rat neurohypophysial nerve terminal populations identified by size, electrophysiological properties and neuropeptide content.
.
Brain Res. 1024(1-2):203-11.
Speigel IA
,
Patel K
,
Hemmings HC
. 2022.
Distinct effects of volatile and intravenous anaesthetics on presynaptic calcium dynamics in mouse hippocampal GABAergic neurones.
.
Br J Anaesth. 128(6):1019-1028.
S Bullock A
,
Platholi J
,
Gjyrezi A
,
Heerdt PM
,
Tung HYLim
,
Hemmings HC
. 2007.
Differential regulation of protein phosphatase-1(I) by neurabin.
.
Biochem Biophys Res Commun. 358(1):140-4.
Lingamaneni R
,
Hemmings HC
. 2003.
Differential interaction of anaesthetics and antiepileptic drugs with neuronal Na+ channels, Ca2+ channels, and GABA(A) receptors.
.
Br J Anaesth. 90(2):199-211.
Zhou C
,
Johnson KW
,
Herold KF
,
Hemmings HC
. 2019.
Differential Inhibition of Neuronal Sodium Channel Subtypes by the General Anesthetic Isoflurane.
.
J Pharmacol Exp Ther. 369(2):200-211.
Ratnakumari L
,
Vysotskaya TN
,
Duch DS
,
Hemmings HC
. 2000.
Differential effects of anesthetic and nonanesthetic cyclobutanes on neuronal voltage-gated sodium channels.
.
Anesthesiology. 92(2):529-41.
Foster GA
,
Schultzberg M
,
Hökfelt T
,
Goldstein M
,
Hemmings HC
,
Ouimet CC
,
Walaas SI
,
Greengard P
. 1987.
Development of a dopamine- and cyclic adenosine 3':5'-monophosphate-regulated phosphoprotein (DARPP-32) in the prenatal rat central nervous system, and its relationship to the arrival of presumptive dopaminergic innervation.
.
J Neurosci. 7(7):1994-2018.
OuYang W
,
Hemmings HC
. 2005.
Depression by isoflurane of the action potential and underlying voltage-gated ion currents in isolated rat neurohypophysial nerve terminals.
.
J Pharmacol Exp Ther. 312(2):801-8.
Stone RA
,
Laties AM
,
Hemmings HC
,
Ouimet CC
,
Greengard P
. 1986.
DARPP-32 in the ciliary epithelium of the eye: a neurotransmitter-regulated phosphoprotein of brain localizes to secretory cells.
.
J Histochem Cytochem. 34(11):1465-8.
Matovcik LM
,
Hemmings HC
,
Kinder BK
. 1995.
DARPP-32 (dopamine and cAMP-regulated phosphoprotein, M(r) 32,000) is a membrane protein in the bovine parathyroid.
.
FEBS Lett. 364(1):67-74.
Hökfelt T
,
Foster G
,
Schultzberg M
,
Meister B
,
Schalling M
,
Goldstein M
,
Hemmings HC
,
Ouimet C
,
Greengard P
. 1988.
DARPP-32 as a marker for D-1 dopaminoceptive cells in the rat brain: prenatal development and presence in glial elements (tanycytes) in the basal hypothalamus.
.
Adv Exp Med Biol. 235:65-82.
Nairn AC
,
Hemmings HC
,
Walaas SI
,
Greengard P
. 1988.
DARPP-32 and phosphatase inhibitor-1, two structurally related inhibitors of protein phosphatase-1, are both present in striatonigral neurons.
.
J Neurochem. 50(1):257-62.
Hemmings HC
,
Greengard P
. 1986.
DARPP-32, a dopamine-regulated phosphoprotein.
.
Prog Brain Res. 69:149-59.
Hemmings HC
,
Greengard P
,
Tung HY
,
Cohen P
. 1984.
DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1.
.
Nature. 310(5977):503-5.
Williams KR
,
Hemmings HC
,
LoPresti MB
,
Konigsberg WH
,
Greengard P
. 1986.
DARPP-32, a dopamine- and cyclic AMP-regulated neuronal phosphoprotein. Primary structure and homology with protein phosphatase inhibitor-1.
.
J Biol Chem. 261(4):1890-903.
Hemmings HC
,
Greengard P
. 1986.
DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein: regional, tissue, and phylogenetic distribution.
.
J Neurosci. 6(5):1469-81.
Hemmings HC
,
Nairn AC
,
Aswad DW
,
Greengard P
. 1984.
DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. II. Purification and characterization of the phosphoprotein from bovine caudate nucleus.
.
J Neurosci. 4(1):99-110.
Ouimet CC
,
Miller PE
,
Hemmings HC
,
Walaas SI
,
Greengard P
. 1984.
DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. III. Immunocytochemical localization.
.
J Neurosci. 4(1):111-24.
Hemmings HC
,
Williams KR
,
Konigsberg WH
,
Greengard P
. 1984.
DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated neuronal phosphoprotein. I. Amino acid sequence around the phosphorylated threonine.
.
J Biol Chem. 259(23):14486-90.
Hemmings HC
,
Nairn AC
,
Greengard P
. 1984.
DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated neuronal phosphoprotein. II. Comparison of the kinetics of phosphorylation of DARPP-32 and phosphatase inhibitor 1.
.
J Biol Chem. 259(23):14491-7.
Hotte M
,
Thuault S
,
Lachaise F
,
Dineley KT
,
Hemmings HC
,
Nairn AC
,
Jay TM
. 2006.
D1 receptor modulation of memory retrieval performance is associated with changes in pCREB and pDARPP-32 in rat prefrontal cortex.
.
Behav Brain Res. 171(1):127-33.
C
Fitch W
,
Smith G
,
Hunter JM
,
Reilly CS
,
Mahajan RP
,
Hemmings HC
. 2023.
Corrigendum to 'The evolution of the British Journal of Anaesthesia: the first 100 years' [Br J Anaesth 2023; 130: 3-7].
.
Br J Anaesth. 130(4):495.
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