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Interneuron diversity
Sodium channels as anesthetic targets
Volatile anesthetic effects on intracellular Ca2+ dynamics influence synaptic vesicle exocytosis
Volatile anesthetics directly bind Nav
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Role of genetic polymorphisms in anesthetic-induced effects on synaptic function and structure.
Spine plasticity in anesthetic action
Voltage gated sodium channels (Nav) and hyperexcitability in early Alzheimer Disease.
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Found 99 results
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Hemmings, H C
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Lingamaneni R
,
Birch ML
,
Hemmings HC
. 2001.
Widespread inhibition of sodium channel-dependent glutamate release from isolated nerve terminals by isoflurane and propofol.
.
Anesthesiology. 95(6):1460-6.
V
Fu D
,
Vissavajjhala P
,
Hemmings HC
. 2005.
Volatile anaesthetic effects on phospholipid binding to synaptotagmin 1, a presynaptic Ca2+ sensor.
.
Br J Anaesth. 95(2):216-21.
T
Soriano SG
,
Vutskits L
,
Jevtovic-Todorovic V
,
Hemmings HC
. 2017.
Thinking, fast and slow: highlights from the 2016 BJA seminar on anaesthetic neurotoxicity and neuroplasticity.
.
Br J Anaesth. 119(3):443-447.
S
Hemmings HC
,
Nairn AC
,
Elliott JI
,
Greengard P
. 1990.
Synthetic peptide analogs of DARPP-32 (Mr 32,000 dopamine- and cAMP-regulated phosphoprotein), an inhibitor of protein phosphatase-1. Phosphorylation, dephosphorylation, and inhibitory activity.
.
J Biol Chem. 265(33):20369-76.
Chang S
,
Hemmings HC
,
Aderem A
. 1996.
Stimulus-dependent phosphorylation of MacMARCKS, a protein kinase C substrate, in nerve termini and PC12 cells.
.
J Biol Chem. 271(2):1174-8.
Hvalby O
,
Hemmings HC
,
Paulsen O
,
Czernik AJ
,
Nairn AC
,
Godfraind JM
,
Jensen V
,
Raastad M
,
Storm JF
,
Andersen P
. 1994.
Specificity of protein kinase inhibitor peptides and induction of long-term potentiation.
.
Proc Natl Acad Sci U S A. 91(11):4761-5.
Hemmings HC
,
Jevtovic-Todorovic V
. 2013.
Special issue on anaesthetic neurotoxicity and neuroplasticity.
.
Br J Anaesth. 110 Suppl 1:i1-2.
Buggy DJ
,
Hemmings HC
. 2014.
Special issue on anaesthesia and cancer.
.
Br J Anaesth. 113 Suppl 1:i1-3.
Hemmings HC
. 2009.
Sodium channels and the synaptic mechanisms of inhaled anaesthetics.
.
Br J Anaesth. 103(1):61-9.
R
Hemmings HC
,
Nairn AC
,
McGuinness TL
,
Huganir RL
,
Greengard P
. 1989.
Role of protein phosphorylation in neuronal signal transduction.
.
FASEB J. 3(5):1583-92.
McAvoy T
,
Allen PB
,
Obaishi H
,
Nakanishi H
,
Takai Y
,
Greengard P
,
Nairn AC
,
Hemmings HC
. 1999.
Regulation of neurabin I interaction with protein phosphatase 1 by phosphorylation.
.
Biochemistry. 38(39):12943-9.
Westphalen RI
,
Krivitski M
,
Amarosa A
,
Guy N
,
Hemmings HC
. 2007.
Reduced inhibition of cortical glutamate and GABA release by halothane in mice lacking the K+ channel, TREK-1.
.
Br J Pharmacol. 152(6):939-45.
P
Nairn AC
,
Hemmings HC
,
Greengard P
. 1985.
Protein kinases in the brain.
.
Annu Rev Biochem. 54:931-76.
Hemmings HC
,
Nairn AC
,
Greengard P
. 1986.
Protein kinases and phosphoproteins in the nervous system.
.
Res Publ Assoc Res Nerv Ment Dis. 64:47-69.
Westphalen RI
,
Desai KM
,
Hemmings HC
. 2013.
Presynaptic inhibition of the release of multiple major central nervous system neurotransmitter types by the inhaled anaesthetic isoflurane.
.
Br J Anaesth. 110(4):592-9.
Bibb JA
,
Snyder GL
,
Nishi A
,
Yan Z
,
Meijer L
,
Fienberg AA
,
Tsai LH
,
Kwon YT
,
Girault JA
,
Czernik AJ
et al.
. 1999.
Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons.
.
Nature. 402(6762):669-71.
Girault JA
,
Hemmings HC
,
Williams KR
,
Nairn AC
,
Greengard P
. 1989.
Phosphorylation of DARPP-32, a dopamine- and cAMP-regulated phosphoprotein, by casein kinase II.
.
J Biol Chem. 264(36):21748-59.
Aperia A
,
Fryckstedt J
,
Svensson L
,
Hemmings HC
,
Nairn AC
,
Greengard P
. 1991.
Phosphorylated Mr 32,000 dopamine- and cAMP-regulated phosphoprotein inhibits Na+,K(+)-ATPase activity in renal tubule cells.
.
Proc Natl Acad Sci U S A. 88(7):2798-801.
O
Jovanovic JN
,
Sihra TS
,
Nairn AC
,
Hemmings HC
,
Greengard P
,
Czernik AJ
. 2001.
Opposing changes in phosphorylation of specific sites in synapsin I during Ca2+-dependent glutamate release in isolated nerve terminals.
.
J Neurosci. 21(20):7944-53.
Foster GA
,
Schultzberg M
,
Kökfelt T
,
Goldstein M
,
Hemmings HC
,
Ouimet CC
,
Walaas SI
,
Greengard P
. 1988.
Ontogeny of the dopamine and cyclic adenosine-3':5'-monophosphate-regulated phosphoprotein (DARPP-32) in the pre- and postnatal mouse central nervous system.
.
Int J Dev Neurosci. 6(4):367-86.
N
Westphalen RI
,
Gomez RS
,
Hemmings HC
. 2009.
Nicotinic receptor-evoked hippocampal norepinephrine release is highly sensitive to inhibition by isoflurane.
.
Br J Anaesth. 102(3):355-60.
Pryor KO
,
Hemmings HC
. 2014.
NAP5: intraoperative awareness detected, and undetected.
.
Br J Anaesth. 113(4):530-3.
M
Agnati LF
,
Fuxe K
,
Zoli M
,
Ferraguti F
,
Benfenati F
,
Ouimet CC
,
Walaas SI
,
Hemmings HC
,
Goldstein M
,
Greengard P
. 1988.
Morphometrical evidence for a complex organization of tyrosine hydroxylase-, enkephalin- and DARPP-32-like immunoreactive patches and their codistribution at three rostrocaudal levels in the rat neostriatum.
.
Neuroscience. 27(3):785-97.
Surmeier DJ
,
Bargas J
,
Hemmings HC
,
Nairn AC
,
Greengard P
. 1995.
Modulation of calcium currents by a D1 dopaminergic protein kinase/phosphatase cascade in rat neostriatal neurons.
.
Neuron. 14(2):385-97.
Kurata J
,
Hemmings HC
. 2015.
Memory and awareness in anaesthesia.
.
Br J Anaesth. 115 Suppl 1:i1-i3.
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