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Interneuron diversity
Sodium channels as anesthetic targets
Volatile anesthetic effects on intracellular Ca2+ dynamics influence synaptic vesicle exocytosis
Volatile anesthetics directly bind Nav
Dr. Platholi's Research Projects
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Role of genetic polymorphisms in anesthetic-induced effects on synaptic function and structure.
Spine plasticity in anesthetic action
Voltage gated sodium channels (Nav) and hyperexcitability in early Alzheimer Disease.
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S
Shahani SK
,
Lingamaneni R
,
Hemmings HC
. 2002.
General anesthetic actions on norepinephrine, dopamine, and gamma-aminobutyric acid transporters in stably transfected cells.
.
Anesth Analg. 95(4):893-9,tableofcontents.
Snyder GL
,
Galdi S
,
Hendrick JP
,
Hemmings HC
. 2007.
General anesthetics selectively modulate glutamatergic and dopaminergic signaling via site-specific phosphorylation in vivo.
.
Neuropharmacology. 53(5):619-30.
Soriano SG
,
Vutskits L
,
Jevtovic-Todorovic V
,
Hemmings HC
. 2017.
Thinking, fast and slow: highlights from the 2016 BJA seminar on anaesthetic neurotoxicity and neuroplasticity.
.
Br J Anaesth. 119(3):443-447.
Stone RA
,
Laties AM
,
Hemmings HC
,
Ouimet CC
,
Greengard P
. 1986.
DARPP-32 in the ciliary epithelium of the eye: a neurotransmitter-regulated phosphoprotein of brain localizes to secretory cells.
.
J Histochem Cytochem. 34(11):1465-8.
Strålfors P
,
Hemmings HC
,
Greengard P
. 1989.
Inhibitors of protein phosphatase-1. Inhibitor-1 of bovine adipose tissue and a dopamine- and cAMP-regulated phosphoprotein of bovine brain are identical.
.
Eur J Biochem. 180(1):143-8.
Surmeier DJ
,
Bargas J
,
Hemmings HC
,
Nairn AC
,
Greengard P
. 1995.
Modulation of calcium currents by a D1 dopaminergic protein kinase/phosphatase cascade in rat neostriatal neurons.
.
Neuron. 14(2):385-97.
T
Tibbs GR
,
Rowley TJ
,
R Sanford L
,
Herold KF
,
Proekt A
,
Hemmings HC
,
Andersen OS
,
Goldstein PA
,
Flood PD
. 2013.
HCN1 channels as targets for anesthetic and nonanesthetic propofol analogs in the amelioration of mechanical and thermal hyperalgesia in a mouse model of neuropathic pain.
.
J Pharmacol Exp Ther. 345(3):363-73.
Torturo CL
,
Zhou Z-Y
,
Ryan TA
,
Hemmings HC
. 2019.
Isoflurane Inhibits Dopaminergic Synaptic Vesicle Exocytosis Coupled to Ca2.1 and Ca2.2 in Rat Midbrain Neurons.
.
eNeuro. 6(1)
Twersky RS
,
Hemmings HC
. 2009.
Introduction: 2009 BJA/PGA Supplement: a selection of eight reviews.
.
Br J Anaesth. 103 Suppl 1:i1-2.
W
Walaas SIvar
,
Hemmings HCaroll
,
Greengard P
,
Nairn AClark
. 2011.
Beyond the dopamine receptor: regulation and roles of serine/threonine protein phosphatases.
.
Front Neuroanat. 5:50.
Wei L
,
Schlame M
,
Downes H
,
Hemmings HC
. 1996.
CHEB, a convulsant barbiturate, evokes calcium-dependent spontaneous glutamate release from rat cerebrocortical synaptosomes.
.
Neuropharmacology. 35(6):695-701.
Westphalen RI
,
Hemmings HC
. 2003.
Selective depression by general anesthetics of glutamate versus GABA release from isolated cortical nerve terminals.
.
J Pharmacol Exp Ther. 304(3):1188-96.
Westphalen RI
,
Gomez RS
,
Hemmings HC
. 2009.
Nicotinic receptor-evoked hippocampal norepinephrine release is highly sensitive to inhibition by isoflurane.
.
Br J Anaesth. 102(3):355-60.
Westphalen RI
,
Yu J
,
Krivitski M
,
Jih T-Y
,
Hemmings HC
. 2010.
Regional differences in nerve terminal Na+ channel subtype expression and Na+ channel-dependent glutamate and GABA release in rat CNS.
.
J Neurochem. 113(6):1611-20.
Westphalen RI
,
Hemmings HC
. 2006.
Volatile anesthetic effects on glutamate versus GABA release from isolated rat cortical nerve terminals: 4-aminopyridine-evoked release.
.
J Pharmacol Exp Ther. 316(1):216-23.
Westphalen RI
,
Desai KM
,
Hemmings HC
. 2013.
Presynaptic inhibition of the release of multiple major central nervous system neurotransmitter types by the inhaled anaesthetic isoflurane.
.
Br J Anaesth. 110(4):592-9.
Westphalen RI
,
Hemmings HC
. 2006.
Volatile anesthetic effects on glutamate versus GABA release from isolated rat cortical nerve terminals: basal release.
.
J Pharmacol Exp Ther. 316(1):208-15.
Westphalen RI
,
Krivitski M
,
Amarosa A
,
Guy N
,
Hemmings HC
. 2007.
Reduced inhibition of cortical glutamate and GABA release by halothane in mice lacking the K+ channel, TREK-1.
.
Br J Pharmacol. 152(6):939-45.
Westphalen RI
,
Hemmings HC
. 2003.
Effects of isoflurane and propofol on glutamate and GABA transporters in isolated cortical nerve terminals.
.
Anesthesiology. 98(2):364-72.
Westphalen RI
,
Kwak N-B
,
Daniels K
,
Hemmings HC
. 2011.
Regional differences in the effects of isoflurane on neurotransmitter release.
.
Neuropharmacology. 61(4):699-706.
Williams KR
,
Hemmings HC
,
LoPresti MB
,
Konigsberg WH
,
Greengard P
. 1986.
DARPP-32, a dopamine- and cyclic AMP-regulated neuronal phosphoprotein. Primary structure and homology with protein phosphatase inhibitor-1.
.
J Biol Chem. 261(4):1890-903.
Williams KR
,
Hemmings HC
,
LoPresti MB
,
Greengard P
. 1989.
ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions. I. Amino acid sequence of ARPP-21B from bovine caudate nucleus.
.
J Neurosci. 9(10):3631-7.
Wong CA
,
S Moonesinghe R
,
Boer C
,
Hemmings HC
,
Hunter JM
. 2020.
Women in anaesthesia, a special issue of the British Journal of Anaesthesia.
.
Br J Anaesth. 124(3):e40-e43.
Y
Yun S-W
,
Platholi J
,
Flaherty MSol
,
Fu W
,
Kottmann AH
,
Toth M
. 2006.
Fmrp is required for the establishment of the startle response during the critical period of auditory development.
.
Brain Res. 1110(1):159-65.
Z
Zhang Y
,
Sharma M
,
Eger EI
,
Laster MJ
,
Hemmings HC
,
R Harris A
. 2008.
Intrathecal veratridine administration increases minimum alveolar concentration in rats.
.
Anesth Analg. 107(3):875-8.
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