Publications

Hemmings HC, Nairn AC, Aswad DW, Greengard P.  1984.  DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. II. Purification and characterization of the phosphoprotein from bovine caudate nucleus.. J Neurosci. 4(1):99-110.

Agnati LF, Fuxe K, Zoli M, Ferraguti F, Benfenati F, Ouimet CC, Walaas SI, Hemmings HC, Goldstein M, Greengard P.  1988.  Morphometrical evidence for a complex organization of tyrosine hydroxylase-, enkephalin- and DARPP-32-like immunoreactive patches and their codistribution at three rostrocaudal levels in the rat neostriatum.. Neuroscience. 27(3):785-97.

Meister B, Fryckstedt J, Schalling M, Cortés R, Hökfelt T, Aperia A, Hemmings HC, Nairn AC, Ehrlich M, Greengard P.  1989.  Dopamine- and cAMP-regulated phosphoprotein (DARPP-32) and dopamine DA1 agonist-sensitive Na+,K+-ATPase in renal tubule cells.. Proc Natl Acad Sci U S A. 86(20):8068-72.

Meister B, Arvidsson U, Hemmings HC, Greengard P, Hökfelt T.  1991.  Dopamine- and adenosine-3':5'-monophosphate (cAMP)-regulated phosphoprotein of Mr 32,000 (DARPP-32) in the retina of cat, monkey and human.. Neurosci Lett. 131(1):66-70.

Meister B, Askergren J, Tunevall G, Hemmings HC, Greengard P.  1991.  Identification of a dopamine- and 3'5'-cyclic adenosine monophosphate-regulated phosphoprotein of 32 kD (DARPP-32) in parathyroid hormone-producing cells of the human parathyroid gland.. J Endocrinol Invest. 14(8):655-61.

Aperia A, Fryckstedt J, Svensson L, Hemmings HC, Nairn AC, Greengard P.  1991.  Phosphorylated Mr 32,000 dopamine- and cAMP-regulated phosphoprotein inhibits Na+,K(+)-ATPase activity in renal tubule cells.. Proc Natl Acad Sci U S A. 88(7):2798-801.

Hemmings HC, Adamo AI.  1994.  Effects of halothane and propofol on purified brain protein kinase C activation.. Anesthesiology. 81(1):147-55.

Hvalby O, Hemmings HC, Paulsen O, Czernik AJ, Nairn AC, Godfraind JM, Jensen V, Raastad M, Storm JF, Andersen P.  1994.  Specificity of protein kinase inhibitor peptides and induction of long-term potentiation.. Proc Natl Acad Sci U S A. 91(11):4761-5.

Hemmings HC, Adamo AI, Hoffman MM.  1995.  Biochemical characterization of the stimulatory effects of halothane and propofol on purified brain protein kinase C.. Anesth Analg. 81(6):1216-22.

Hemmings HC, Adamo AI.  1996.  Activation of endogenous protein kinase C by halothane in synaptosomes.. Anesthesiology. 84(3):652-62.

Lien CA, Hemmings HC, Belmont MR, Abalos A, Hollmann C, Kelly RE.  1996.  A comparison: the efficacy of sevoflurane-nitrous oxide or propofol-nitrous oxide for the induction and maintenance of general anesthesia.. J Clin Anesth. 8(8):639-43.

Chang S, Hemmings HC, Aderem A.  1996.  Stimulus-dependent phosphorylation of MacMARCKS, a protein kinase C substrate, in nerve termini and PC12 cells.. J Biol Chem. 271(2):1174-8.

Hemmings HC, Adamo AI.  1997.  Effect of halothane on conventional protein kinase C translocation and down-regulation in rat cerebrocortical synaptosomes.. Br J Anaesth. 78(2):189-96.

McAvoy T, Allen PB, Obaishi H, Nakanishi H, Takai Y, Greengard P, Nairn AC, Hemmings HC.  1999.  Regulation of neurabin I interaction with protein phosphatase 1 by phosphorylation.. Biochemistry. 38(39):12943-9.

Absil P, Foidart A, Hemmings HC, Steinbusch HW, Ball GF, Balthazart J.  2001.  Distribution of DARPP-32 immunoreactive structures in the quail brain: anatomical relationship with dopamine and aromatase.. J Chem Neuroanat. 21(1):23-39.

Albert KA, Hemmings HC, Adamo AIB, Potkin SG, Akbarian S, Sandman CA, Cotman CW, Bunney WE, Greengard P.  2002.  Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophrenia.. Arch Gen Psychiatry. 59(8):705-12.

Albert KA, Hemmings HC, Adamo AIB, Potkin SG, Akbarian S, Sandman CA, Cotman CW, Bunney WE, Greengard P.  2002.  Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophrenia.. Arch Gen Psychiatry. 59(8):705-12.

Albert KA, Hemmings HC, Adamo AIB, Potkin SG, Akbarian S, Sandman CA, Cotman CW, Bunney WE, Greengard P.  2002.  Evidence for decreased DARPP-32 in the prefrontal cortex of patients with schizophrenia.. Arch Gen Psychiatry. 59(8):705-12.

Bálint E, Kitka T, Zachar G, Adám A, Hemmings HC, Csillag A.  2004.  Abundance and location of DARPP-32 in striato-tegmental circuits of domestic chicks.. J Chem Neuroanat. 28(1-2):27-36.

Hemmings HC, Akabas MH, Goldstein PA, Trudell JR, Orser BA, Harrison NL.  2005.  Emerging molecular mechanisms of general anesthetic action.. Trends Pharmacol Sci. 26(10):503-10.

Hemmings HC, Antognini JF.  2006.  Do general anesthetics add up? Anesthesiology. 104(6):1120-2.

Westphalen RI, Krivitski M, Amarosa A, Guy N, Hemmings HC.  2007.  Reduced inhibition of cortical glutamate and GABA release by halothane in mice lacking the K+ channel, TREK-1.. Br J Pharmacol. 152(6):939-45.

Rusinova R, Herold KF, R Sanford L, Greathouse DV, Hemmings HC, Andersen OS.  2011.  Thiazolidinedione insulin sensitizers alter lipid bilayer properties and voltage-dependent sodium channel function: implications for drug discovery.. J Gen Physiol. 138(2):249-70.

Jevtovic-Todorovic V, Absalom AR, Blomgren K, Brambrink A, Crosby G, Culley DJ, Fiskum G, Giffard RG, Herold KF, Loepke AW et al..  2013.  Anaesthetic neurotoxicity and neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar.. Br J Anaesth. 111(2):143-51.

Tibbs GR, Rowley TJ, R Sanford L, Herold KF, Proekt A, Hemmings HC, Andersen OS, Goldstein PA, Flood PD.  2013.  HCN1 channels as targets for anesthetic and nonanesthetic propofol analogs in the amelioration of mechanical and thermal hyperalgesia in a mouse model of neuropathic pain.. J Pharmacol Exp Ther. 345(3):363-73.