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Interneuron diversity
Sodium channels as anesthetic targets
Volatile anesthetic effects on intracellular Ca2+ dynamics influence synaptic vesicle exocytosis
Volatile anesthetics directly bind Nav
Dr. Platholi's Research Projects
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Role of genetic polymorphisms in anesthetic-induced effects on synaptic function and structure.
Spine plasticity in anesthetic action
Voltage gated sodium channels (Nav) and hyperexcitability in early Alzheimer Disease.
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Found 24 results
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Year
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1988
Meister B, Fried G, Hökfelt T, Hemmings HC, Greengard P
. 1988.
Immunohistochemical evidence for the existence of a dopamine- and cyclic AMP-regulated phosphoprotein (DARPP-32) in brown adipose tissue of pigs.
.
Proc Natl Acad Sci U S A. 85(22):8713-6.
1989
Strålfors P, Hemmings HC, Greengard P
. 1989.
Inhibitors of protein phosphatase-1. Inhibitor-1 of bovine adipose tissue and a dopamine- and cAMP-regulated phosphoprotein of bovine brain are identical.
.
Eur J Biochem. 180(1):143-8.
1991
Meister B, Askergren J, Tunevall G, Hemmings HC, Greengard P
. 1991.
Identification of a dopamine- and 3'5'-cyclic adenosine monophosphate-regulated phosphoprotein of 32 kD (DARPP-32) in parathyroid hormone-producing cells of the human parathyroid gland.
.
J Endocrinol Invest. 14(8):655-61.
Gustafson EL, Girault JA, Hemmings HC, Nairn AC, Greengard P
. 1991.
Immunocytochemical localization of phosphatase inhibitor-1 in rat brain.
.
J Comp Neurol. 310(2):170-88.
1994
Fisone G, Cheng SX, Nairn AC, Czernik AJ, Hemmings HC, Höög JO, Bertorello AM, Kaiser R, Bergman T, Jörnvall H
. 1994.
Identification of the phosphorylation site for cAMP-dependent protein kinase on Na+,K(+)-ATPase and effects of site-directed mutagenesis.
.
J Biol Chem. 269(12):9368-73.
1995
Schlame M, Hemmings HC
. 1995.
Inhibition by volatile anesthetics of endogenous glutamate release from synaptosomes by a presynaptic mechanism.
.
Anesthesiology. 82(6):1406-16.
1996
Ratnakumari L, Hemmings HC
. 1996.
Inhibition by propofol of [3H]-batrachotoxinin-A 20-alpha-benzoate binding to voltage-dependent sodium channels in rat cortical synaptosomes.
.
Br J Pharmacol. 119(7):1498-504.
1998
Ratnakumari L, Hemmings HC
. 1998.
Inhibition of presynaptic sodium channels by halothane.
.
Anesthesiology. 88(4):1043-54.
2000
Lingameneni R, Vysotskaya TN, Duch DS, Hemmings HC
. 2000.
Inhibition of voltage-dependent sodium channels by Ro 31-8220, a 'specific' protein kinase C inhibitor.
.
FEBS Lett. 473(2):265-8.
2003
OuYang W, Wang G, Hemmings HC
. 2003.
Isoflurane and propofol inhibit voltage-gated sodium channels in isolated rat neurohypophysial nerve terminals.
.
Mol Pharmacol. 64(2):373-81.
2007
OuYang W, Jih T-Y, Zhang T-T, Correa AM, Hemmings HC
. 2007.
Isoflurane inhibits NaChBac, a prokaryotic voltage-gated sodium channel.
.
J Pharmacol Exp Ther. 322(3):1076-83.
OuYang W, Hemmings HC
. 2007.
Isoform-selective effects of isoflurane on voltage-gated Na+ channels.
.
Anesthesiology. 107(1):91-8.
2008
Zhang Y, Sharma M, Eger EI, Laster MJ, Hemmings HC, R Harris A
. 2008.
Intrathecal veratridine administration increases minimum alveolar concentration in rats.
.
Anesth Analg. 107(3):875-8.
2009
Twersky RS, Hemmings HC
. 2009.
Introduction: 2009 BJA/PGA Supplement: a selection of eight reviews.
.
Br J Anaesth. 103 Suppl 1:i1-2.
Herold KF, Nau C, OuYang W, Hemmings HC
. 2009.
Isoflurane inhibits the tetrodotoxin-resistant voltage-gated sodium channel Nav1.8.
.
Anesthesiology. 111(3):591-9.
2013
Pryor KO, Hemmings HC
. 2013.
Increased risk of awareness under anesthesia: an issue of consciousness or of memory?
Anesthesiology. 119(6):1236-8.
2014
Platholi J, Herold KF, Hemmings HC, Halpain S
. 2014.
Isoflurane reversibly destabilizes hippocampal dendritic spines by an actin-dependent mechanism.
.
PLoS One. 9(7):e102978.
2015
Giambrone GP, Hemmings HC, Sturm M, Fleischut PM
. 2015.
Information technology innovation: the power and perils of big data.
.
Br J Anaesth. 115(3):339-42.
Baumgart JP, Zhou Z-Y, Hara M, Cook DC, Hoppa MB, Ryan TA, Hemmings HC
. 2015.
Isoflurane inhibits synaptic vesicle exocytosis through reduced Ca2+ influx, not Ca2+-exocytosis coupling.
.
Proc Natl Acad Sci U S A. 112(38):11959-64.
2017
Sand RM, Gingrich KJ, Macharadze T, Herold KF, Hemmings HC
. 2017.
Isoflurane modulates activation and inactivation gating of the prokaryotic Na channel NaChBac.
.
J Gen Physiol. 149(6):623-638.
2019
Torturo CL, Zhou Z-Y, Ryan TA, Hemmings HC
. 2019.
Isoflurane Inhibits Dopaminergic Synaptic Vesicle Exocytosis Coupled to Ca2.1 and Ca2.2 in Rat Midbrain Neurons.
.
eNeuro. 6(1)
Zhao W, Zhang M, Liu J, Liang P, Wang R, Hemmings HC, Zhou C
. 2019.
Isoflurane Modulates Hippocampal Cornu Ammonis Pyramidal Neuron Excitability by Inhibition of Both Transient and Persistent Sodium Currents in Mice.
.
Anesthesiology. 131(1):94-104.
2021
Zhao W, Zhao S, Zhu T, Ou M, Zhang D, Sun H, Liu J, Chen X, Hemmings HC, Zhou C
. 2021.
Isoflurane Suppresses Hippocampal High-frequency Ripples by Differentially Modulating Pyramidal Neurons and Interneurons in Mice.
.
Anesthesiology. 135(1):122-135.
2023
Osman V, Speigel I, Patel K, Hemmings HC
. 2023.
Isoflurane Alters Presynaptic Endoplasmic Reticulum Calcium Dynamics in Wild-Type and Malignant Hyperthermia-Susceptible Rodent Hippocampal Neurons.
.
eNeuro. 10(8)