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Interneuron diversity
Sodium channels as anesthetic targets
Volatile anesthetic effects on intracellular Ca2+ dynamics influence synaptic vesicle exocytosis
Volatile anesthetics directly bind Nav
Dr. Platholi's Research Projects
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Role of genetic polymorphisms in anesthetic-induced effects on synaptic function and structure.
Spine plasticity in anesthetic action
Voltage gated sodium channels (Nav) and hyperexcitability in early Alzheimer Disease.
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S
Westphalen RI
,
Hemmings HC
. 2003.
Selective depression by general anesthetics of glutamate versus GABA release from isolated cortical nerve terminals.
.
J Pharmacol Exp Ther. 304(3):1188-96.
R
Koyanagi Y
,
Torturo CL
,
Cook DC
,
Zhou Z
,
Hemmings HC
. 2019.
Role of specific presynaptic calcium channel subtypes in isoflurane inhibition of synaptic vesicle exocytosis in rat hippocampal neurones.
.
Br J Anaesth. 123(2):219-227.
Hemmings HC
,
Nairn AC
,
McGuinness TL
,
Huganir RL
,
Greengard P
. 1989.
Role of protein phosphorylation in neuronal signal transduction.
.
FASEB J. 3(5):1583-92.
Hemmings HC
,
Mackie K
. 2011.
The rivers of Lethe and Mnemosyne converge: propofol and memory consolidation.
.
Anesthesiology. 114(6):1277-9.
Speigel IA
,
Hemmings HC
. 2021.
Relevance of Cortical and Hippocampal Interneuron Functional Diversity to General Anesthetic Mechanisms: A Narrative Review.
.
Front Synaptic Neurosci. 13:812905.
Riegelhaupt PM
,
Hemmings HC
,
Goldstein PA
. 2016.
Relevance of Clinical Relevance.
.
Anesthesiology. 125(4):821-2.
Nguyen C
,
Nishi A
,
Kansy JW
,
Fernandez J
,
Hayashi K
,
Gillardon F
,
Hemmings HC
,
Nairn AC
,
Bibb JA
. 2007.
Regulation of protein phosphatase inhibitor-1 by cyclin-dependent kinase 5.
.
J Biol Chem. 282(22):16511-20.
Platholi J
,
Federman A
,
Detert JA
,
Heerdt P
,
Hemmings HC
. 2014.
Regulation of protein phosphatase 1I by Cdc25C-associated kinase 1 (C-TAK1) and PFTAIRE protein kinase.
.
J Biol Chem. 289(34):23893-900.
McAvoy T
,
Allen PB
,
Obaishi H
,
Nakanishi H
,
Takai Y
,
Greengard P
,
Nairn AC
,
Hemmings HC
. 1999.
Regulation of neurabin I interaction with protein phosphatase 1 by phosphorylation.
.
Biochemistry. 38(39):12943-9.
Hazlett EA
,
Buchsbaum MS
,
Hsieh P
,
M Haznedar M
,
Platholi J
,
LiCalzi EM
,
Cartwright C
,
Hollander E
. 2004.
Regional glucose metabolism within cortical Brodmann areas in healthy individuals and autistic patients.
.
Neuropsychobiology. 49(3):115-25.
Westphalen RI
,
Kwak N-B
,
Daniels K
,
Hemmings HC
. 2011.
Regional differences in the effects of isoflurane on neurotransmitter release.
.
Neuropharmacology. 61(4):699-706.
Westphalen RI
,
Yu J
,
Krivitski M
,
Jih T-Y
,
Hemmings HC
. 2010.
Regional differences in nerve terminal Na+ channel subtype expression and Na+ channel-dependent glutamate and GABA release in rat CNS.
.
J Neurochem. 113(6):1611-20.
Westphalen RI
,
Krivitski M
,
Amarosa A
,
Guy N
,
Hemmings HC
. 2007.
Reduced inhibition of cortical glutamate and GABA release by halothane in mice lacking the K+ channel, TREK-1.
.
Br J Pharmacol. 152(6):939-45.
Morrow PW
,
Tung HYLim
,
Hemmings HC
. 2004.
Rapamycin causes activation of protein phosphatase-2A1 and nuclear translocation of PCNA in CD4+ T cells.
.
Biochem Biophys Res Commun. 323(2):645-51.
P
Zhang TT
,
Platholi J
,
Heerdt PM
,
Hemmings HC
,
Tung HYL
. 2008.
Protein phosphatase-2A is activated in pig brain following cardiac arrest and resuscitation.
.
Metab Brain Dis. 23(1):95-104.
Nairn AC
,
Hemmings HC
,
Greengard P
. 1985.
Protein kinases in the brain.
.
Annu Rev Biochem. 54:931-76.
Hemmings HC
,
Nairn AC
,
Greengard P
. 1986.
Protein kinases and phosphoproteins in the nervous system.
.
Res Publ Assoc Res Nerv Ment Dis. 64:47-69.
Westphalen RI
,
Desai KM
,
Hemmings HC
. 2013.
Presynaptic inhibition of the release of multiple major central nervous system neurotransmitter types by the inhaled anaesthetic isoflurane.
.
Br J Anaesth. 110(4):592-9.
Pearse RM
,
Ackland GL
,
Asai T
,
Hemmings HC
. 2021.
Preprints in perioperative medicine: immediacy for the greater good.
.
Br J Anaesth. 126(5):915-918.
Buchsbaum MS
,
Hollander E
,
Pallanti S
,
Rossi NBaldini
,
Platholi J
,
Newmark R
,
Bloom R
,
Sood E
. 2006.
Positron emission tomography imaging of risperidone augmentation in serotonin reuptake inhibitor-refractory patients.
.
Neuropsychobiology. 53(3):157-68.
Hemmings HC
,
Greengard P
. 2010.
Positively active: how local anesthetics work.
.
Anesthesiology. 113(1):250-2.
Ingólfsson HI
,
Thakur P
,
Herold KF
,
E Hobart A
,
Ramsey NB
,
Periole X
,
de Jong DH
,
Zwama M
,
Yilmaz D
,
Hall K
et al.
. 2014.
Phytochemicals perturb membranes and promiscuously alter protein function.
.
ACS Chem Biol. 9(8):1788-98.
Futter M
,
Uematsu K
,
Bullock SA
,
Kim Y
,
Hemmings HC
,
Nishi A
,
Greengard P
,
Nairn AC
. 2005.
Phosphorylation of spinophilin by ERK and cyclin-dependent PK 5 (Cdk5).
.
Proc Natl Acad Sci U S A. 102(9):3489-94.
Bibb JA
,
Snyder GL
,
Nishi A
,
Yan Z
,
Meijer L
,
Fienberg AA
,
Tsai LH
,
Kwon YT
,
Girault JA
,
Czernik AJ
et al.
. 1999.
Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons.
.
Nature. 402(6762):669-71.
Girault JA
,
Hemmings HC
,
Williams KR
,
Nairn AC
,
Greengard P
. 1989.
Phosphorylation of DARPP-32, a dopamine- and cAMP-regulated phosphoprotein, by casein kinase II.
.
J Biol Chem. 264(36):21748-59.
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