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Interneuron diversity
Sodium channels as anesthetic targets
Volatile anesthetic effects on intracellular Ca2+ dynamics influence synaptic vesicle exocytosis
Volatile anesthetics directly bind Nav
Dr. Platholi's Research Projects
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Role of genetic polymorphisms in anesthetic-induced effects on synaptic function and structure.
Spine plasticity in anesthetic action
Voltage gated sodium channels (Nav) and hyperexcitability in early Alzheimer Disease.
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Publications
Found 191 results
Author
Title
Type
Year
2009
Perouansky M
,
Hemmings HC
. 2009.
Between Clotho and Lachesis: how isoflurane seals neuronal fate.
.
Anesthesiology. 110(4):709-11.
OuYang W
,
Herold KF
,
Hemmings HC
. 2009.
Comparative effects of halogenated inhaled anesthetics on voltage-gated Na+ channel function.
.
Anesthesiology. 110(3):582-90.
Twersky RS
,
Hemmings HC
. 2009.
Introduction: 2009 BJA/PGA Supplement: a selection of eight reviews.
.
Br J Anaesth. 103 Suppl 1:i1-2.
Herold KF
,
Nau C
,
OuYang W
,
Hemmings HC
. 2009.
Isoflurane inhibits the tetrodotoxin-resistant voltage-gated sodium channel Nav1.8.
.
Anesthesiology. 111(3):591-9.
Perouansky M
,
Hemmings HC
. 2009.
Neurotoxicity of general anesthetics: cause for concern?
Anesthesiology. 111(6):1365-71.
Westphalen RI
,
Gomez RS
,
Hemmings HC
. 2009.
Nicotinic receptor-evoked hippocampal norepinephrine release is highly sensitive to inhibition by isoflurane.
.
Br J Anaesth. 102(3):355-60.
Hemmings HC
. 2009.
Sodium channels and the synaptic mechanisms of inhaled anaesthetics.
.
Br J Anaesth. 103(1):61-9.
2008
Platholi J
,
Heerdt PM
,
Tung HYLim
,
Hemmings HC
. 2008.
Activation of brain protein phosphatase-1(I) following cardiac arrest and resuscitation involving an interaction with 14-3-3 gamma.
.
J Neurochem. 105(5):2029-38.
Hemmings HC
,
Flood P
. 2008.
Galloping in full pursuit of the mechanism of anesthetic immobility.
.
Anesthesiology. 108(6):975-6.
Zhang Y
,
Sharma M
,
Eger EI
,
Laster MJ
,
Hemmings HC
,
R Harris A
. 2008.
Intrathecal veratridine administration increases minimum alveolar concentration in rats.
.
Anesth Analg. 107(3):875-8.
Eger EI
,
Raines DE
,
Shafer SL
,
Hemmings HC
,
Sonner JM
. 2008.
Is a new paradigm needed to explain how inhaled anesthetics produce immobility?
Anesth Analg. 107(3):832-48.
Zhang TT
,
Platholi J
,
Heerdt PM
,
Hemmings HC
,
Tung HYL
. 2008.
Protein phosphatase-2A is activated in pig brain following cardiac arrest and resuscitation.
.
Metab Brain Dis. 23(1):95-104.
Hemmings HC
,
Mantz J
. 2008.
Xenon and the pharmacology of fear.
.
Anesthesiology. 109(6):954-5.
2007
S Bullock A
,
Platholi J
,
Gjyrezi A
,
Heerdt PM
,
Tung HYLim
,
Hemmings HC
. 2007.
Differential regulation of protein phosphatase-1(I) by neurabin.
.
Biochem Biophys Res Commun. 358(1):140-4.
Snyder GL
,
Galdi S
,
Hendrick JP
,
Hemmings HC
. 2007.
General anesthetics selectively modulate glutamatergic and dopaminergic signaling via site-specific phosphorylation in vivo.
.
Neuropharmacology. 53(5):619-30.
OuYang W
,
Jih T-Y
,
Zhang T-T
,
Correa AM
,
Hemmings HC
. 2007.
Isoflurane inhibits NaChBac, a prokaryotic voltage-gated sodium channel.
.
J Pharmacol Exp Ther. 322(3):1076-83.
OuYang W
,
Hemmings HC
. 2007.
Isoform-selective effects of isoflurane on voltage-gated Na+ channels.
.
Anesthesiology. 107(1):91-8.
Hemmings HC
. 2007.
Noble meets nouveau: a shared anesthetic binding site for xenon and isoflurane on a glutamate receptor.
.
Anesthesiology. 107(5):694-6.
Hotte M
,
Thuault S
,
Dineley KT
,
Hemmings HC
,
Nairn AC
,
Jay TM
. 2007.
Phosphorylation of CREB and DARPP-32 during late LTP at hippocampal to prefrontal cortex synapses in vivo.
.
Synapse. 61(1):24-8.
Westphalen RI
,
Krivitski M
,
Amarosa A
,
Guy N
,
Hemmings HC
. 2007.
Reduced inhibition of cortical glutamate and GABA release by halothane in mice lacking the K+ channel, TREK-1.
.
Br J Pharmacol. 152(6):939-45.
Nguyen C
,
Nishi A
,
Kansy JW
,
Fernandez J
,
Hayashi K
,
Gillardon F
,
Hemmings HC
,
Nairn AC
,
Bibb JA
. 2007.
Regulation of protein phosphatase inhibitor-1 by cyclin-dependent kinase 5.
.
J Biol Chem. 282(22):16511-20.
2006
Bruening S
,
Oh E
,
Hetzenauer A
,
Escobar-Alvarez S
,
Westphalen RI
,
Hemmings HC
,
Singewald N
,
Shippenberg T
,
Toth M
. 2006.
The anxiety-like phenotype of 5-HT receptor null mice is associated with genetic background-specific perturbations in the prefrontal cortex GABA-glutamate system.
.
J Neurochem. 99(3):892-9.
Hotte M
,
Thuault S
,
Lachaise F
,
Dineley KT
,
Hemmings HC
,
Nairn AC
,
Jay TM
. 2006.
D1 receptor modulation of memory retrieval performance is associated with changes in pCREB and pDARPP-32 in rat prefrontal cortex.
.
Behav Brain Res. 171(1):127-33.
Hemmings HC
,
Antognini JF
. 2006.
Do general anesthetics add up?
Anesthesiology. 104(6):1120-2.
Yun S-W
,
Platholi J
,
Flaherty MSol
,
Fu W
,
Kottmann AH
,
Toth M
. 2006.
Fmrp is required for the establishment of the startle response during the critical period of auditory development.
.
Brain Res. 1110(1):159-65.
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